Publications
2024
Marianne Bore Haarr, Kotchakorn T.sriwong, Elaine O’Reilly, “Commercial transaminases for the asymmetric synthesis of bulky amines”, European Journal of Organic Chemistry, 2024, e202400257.
Adam O’Connell, Amber Barry, Ashleigh J Burke, Amy E Hutton, Elizabeth L Bell, Anthony P Green, Elaine O’Reilly, “Biocatalysis: landmark discoveries and applications in chemical synthesis” Chemical Society Reviews, 2024, 53, 2828-2850.
Elizabeth L Bell, Amy E Hutton, Ashleigh J Burke, Adam O’Connell, Amber Barry, Elaine O’Reilly, Anthony P Green, “Strategies for Designing Biocatalysts with New Functions” Chemical Society Reviews, 2024, 53, 2851-2862.
2023
Aoife Martin, Ishita Solanki, Marianne Bore Haarr, Elaine O’Reilly, “Enzyme Triggered Reactions for the Synthesis of Organic Molecules”, European Journal of Organic Chemistry, 2023, 26, e202300858.
Elaine O’Reilly, Marianne B. Haarr, “Hijacking a P450 for Ketone Synthesis”, Nature Catalysis, 2023, 6, 561-562.
Scarlet A. Ferrinho, Samuel A. Molyneux, Rebecca J. M. Goss, Elizabeth L. Bell, Amy Crossley, Anthony P. Green, Kathryn Yeow, Elaine O’Reilly, “Modern Development in Biocatalysis”, Modern Development in Catalysis, Volume 2, Chapter 14.
2022
Kathryn Yeow, Marianne B. Haarr, Jimmy Muldoon, Elaine O’Reilly, “Preparation of iminosugars from aminopolyols via selective oxidation using galactose oxidase”, ChemComm, 2022, 58, 13640-13643.
Elaine O’Reilly, “Building enzymes from scratch“ Nature Chemistry, 2022, 14, 246-248.
Freya Taday, James Ryan, Rachel O’Sullivan, Elaine O’Reilly, “Transaminase-Mediated Amine Borrowing via Shuttle Biocatalysis”, Organic Letters, 2022, 24, 74-79.
Freya Taday, Ryan Cairns, Adam O’Connell, Elaine O’Reilly, “Combining bio- and organocatalysis for the synthesis of piperidine alkaloids” ChemComm, 2022, 58, 1697-1700.
2021
Justyna Kuska, Freya Taday, Kathryn Yeow, James Ryan, Elaine O’Reilly, “An in vitro-in vivo sequential cascade for the synthesis of iminosugars from aldoses”, Catalysis Science & Technology, 2021, 11, 4327-4331.
2020
Justyna Kuska, Elaine O’Reilly, “Engineered biosynthetic pathways and biocatalytic cascades for sustainable synthesis” Current Opinion in Chemical Biology, 2020, 58: 146-154
Stylianos Grigoriou, Pierre Kugler, Evelina Kulcinskaja, Frederik Walter, John King, Phil Hill, Volker F. Wendisch, and Elaine O’Reilly, “Development of a Corynebacterium glutamicum bio-factory for self-sufficient transaminase reactions” Green Chemistry, 2020, 22, 2020.
Freya Taday, James Ryan, Stephen P. Argent, Vittorio Caprio, Beatriz Maciá, Elaine O’Reilly, “Asymmetric Construction of Alkaloids by Employing a Key ω‐Transaminase Cascade” Chemistry a European Journal, 2020, 26, 3729-3732.
2019
Elaine O’Reilly & James Ryan, “Biocatalytic Cascades Go Viral” Science, 2019, 66, 1199-1200 (Full text access here).
Ryan Cairns, Andrew Gomm, James Ryan, Thomas Clarke, Evelina Kulcinskaja, Kevin Butler, Elaine O’Reilly, “Conversion of Aldoses to Valuable omega-Amino Alcohols Using Amine Transaminase Biocatalysts” ACS Catalysis, 2019, 9, 1220-1223 (Front Cover).
Ryan Cairns, Andrew Gomm, Christopher Peel, Michael Sharkey, Elaine O’Reilly, “A Comprehensive Quantitative Assay for Amine Transaminases” ChemCatChem, 2019, 11, 4738-4743.
Harry Eastman, James Ryan, Beatriz Maciá, Vittorio Caprio, Elaine O’Reilly, “Alcohol Dehydrogenase-triggered Oxa-Michael Reaction for the Asymmetric Synthesis of Disubstituted tetrahydropyrans and tetrahydrofurans” ChemCatChem, 2019, 11, 3760-3762 (Special issue celebrating Women of Catalysis)
2018
Andrew Gomm and Elaine O’Reilly, “Transaminases for Chiral Amine Synthesis”, Current Opinion in Chemical Biology, 2018, 43, 106-112.
Andrew Gomm, Stylianos Grigoriou, Christopher Peel, James Ryan, Nafees Mujtaba, Thomas Clarke, Evalina Kulcinskaja, Elaine O’Reilly, “Application of Smart Amine Donors for Rapid Screening and Scale-Up of Transaminase-Mediated Biotransformations” European Journal of Organic Chemistry, 2018, 38, 5282-5284.
2017
Edgar Peris, Obinna Okafor, Evelina Kulcinskaja, Ruth Goodridge, Santiago V. Luis, Eduardo Garcia-Verdugo, Elaine O'Reilly, Victor Sans, "Tuneable 3D printed enzymatic reactors for continuous-flow biotransformations", Green Chemistry, 2017, 19, 5345-5349 (Front cover).
2016
James Ryan, Mindaugas Šiaučiulis, Andrew Gomm, Beatriz Maciá, Elaine O'Reilly, Vittorio Caprio, "Transaminase Triggered Aza-Michael Approach for the Enantioselective Synthesis of Piperidine Scaffolds", J. Am. Chem. Soc. 2016, 138, 15798-15800.
Andrew Gomm, William Lewis, Anthony P. Green, Elaine O'Reilly, "A new generation of smart amine donors for transaminase-mediated biotransformations" Chemistry: A European Journal. 2016, 22, 12692-12695.
Elaine O'Reilly, Nicholas J. Turner, "ω-Transaminase/Monoamine Oxidase Cascade for the chemoenzymatic synthesis of chiral 2,5-Disubstituted Pyrrolidines" Practical Methods in Biocatalysis & Biotransformations. 2016 (Book chapter).
2015
Nicholas J. Turner, Elaine O'Reilly, "Biocatalytic cascades for the Regio- and Stereoselective Synthesis of Chiral 2,5-Disubstituted Pyrrolidines" Perspectives Sci. 2015, 4, 55-61.
2014
Anthony P. Green, Nicholas J. Turner, and Elaine O'Reilly. "Chiral Amine Synthesis Using ω-Transaminases: An Amine Donor that Displaces Equilibria and Enables High-Throughput Screening", Angew. Chem. 2014, 53, 2447-2450 (VIP Article): Highlight in C&E News, 2014, 92, 13: Highlighted in Nat. Chem., 2014, 6, 849 : Selected for F1000Prime.
Elaine O'Reilly, Cesar Iglesias, Diego Ghislieri, Jennifer Hopwood, James L. Galman, Richard C. Lloyd, Nicholas J. Turner, "A Regio- and Stereoselective ω- Transaminase/Monoamine Oxidase Cascade for the Synthesis of Chiral 2,5-Disubstituted Pyrrolidines" Angew. Chem., 2014, 53, 2447-2450 ; Highlighted in Synfacts 2014, 10, 0429.
Elaine O'Reilly, Cesar Iglesias, Nicholas J. Turner, "Monoamine Oxidase/ω-Transaminase Cascade for the Deracemisation and Dealkylation of Amines" ChemCatChem. 2014, 6, 992-995.
2013
Elaine O'Reilly, Mark Corbett, Shahed Hussain, Paul P. Kelly, Dominique Richardson, Sabine L. Flitsch, Nicholas J. Turner, "Substrate Promiscuity of Cytochrome P450 RhF" Cat. Sci. Technol. 2013, 3, 1490-1492.
Nicholas Turner and Elaine O’Reilly, “Biocatalytic Retrosynthesis” Nat. Chem. Biol. 2013, 9, 285-288: Highlighted in C&E News, 2013, 91, 34.
2012
Elaine O’Reilly, Suzanne J. Aitken, Gideon Grogan, Paul P. Kelly, Nicholas J. Turner, Sabine L. Flitsch, “Regio- and Stereoselective Oxidation of Unactivated C–H bonds with Rhodococcus rhodochrous” Beilstein J. Org. Chem. 2012, 8, 496-500: Associated scientific video showcasing research in cytochrome P450 group.
Elaine O’Reilly, Lara Pes, Yannick Ortin, Helge Müller-Bunz, Francesca Paradisi, “Synthesis of a Conformationally Constrained δ-amino Acid Building Block” Amino Acids, 2012, 44,511-518.
2011
Elaine O'Reilly, Valentin Kohler, Sabine Flitsch, Nicholas J. Turner, "Cytochromes P450 as Useful Biocatalysts: Addressing the Limitations" Chem. Commun. 2011, 47, 2490-2501.
Aelig Robin, Valentin Kohler, Alison Jones, Afruja Ali, Paul Kelly, Elaine O'Reilly, Nicholas J. Turner, Sabine L. Flitsch, "Chimeric Self-sufficient P450cam-RhFRed Biocatalysis with Broad Substrate Scope" Beilstein J. Org. Chem. 2011, 1494-1498.
2010
Elaine O'Reilly, Daniele Balducci, Francesca Paradisi, "A Stereoselective Synthesis of α-Deuterium Labelled (S)-α-amino Acids" Amino Acids, 2010, 39, 849-858.
Elaine O'Reilly, Lara Pes, Francesca Paradisi, "From Amines to Diketopiperazines: a One-pot Approach" Tetrahedron Lett. 2010, 51, 1696-1697.
Elaine O'Reilly, Elena Lestini, Daniele Balducci, Francesca Paradisi, "One-step Diketopiperazine Synthesis Using Phase Transfer Catalysis" Tetrahedron Lett. 2009, 50, 1748-1750.